ethyl 1-[[3-bromo-2-(2-[[(trifluoromethyl)sulfonyl]amino]phenyl)-1-benzofuran-5-yl]methyl]-4-cyclopropyl-2-ethyl-1H-imidazole-5-carboxylate
March 24th, 2008Chemical:ethyl 1-[[3-bromo-2-(2-[[(trifluoromethyl)sulfonyl]amino]phenyl)-1-benzofuran-5-yl]methyl]-4-cyclopropyl-2-ethyl-1H-imidazole-5-carboxylate
CAS:
Structure:
Formula:C27H25BrF3N3O5S
Formula mass:640.4806
Synthesis:Target product:Saprisartan, GR-138950C(K salt), GR-138950X, GR-138950
Synthetic route:
Synthetic Methods:1) The reaction of 5-methylbenzofuran (I) with triisopropyl borate by means of butyllithium and tetramethylethylenediamine (TMEDA) in ethyl ether gives 5-methylbenzofuran-2-boronic acid (II), which is condensed with methyl 2-bromobenzoate (III) by means of tetrakis(triphenylphosphine)palladium yielding 2-(5-methylbenzofuran-2-yl)benzoic acid methyl ester (IV). The ...
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ethyl 1-[(3-bromo-2-[2-[(tert-butoxycarbonyl)amino]phenyl]-1-benzofuran-5-yl)methyl]-4-cyclopropyl-2-ethyl-1H-imidazole-5-carboxylate
March 24th, 2008Chemical:ethyl 1-[(3-bromo-2-[2-[(tert-butoxycarbonyl)amino]phenyl]-1-benzofuran-5-yl)methyl]-4-cyclopropyl-2-ethyl-1H-imidazole-5-carboxylate
CAS:
Structure:
Formula:C31H34BrN3O5
Formula mass:608.5377
Synthesis:
Target product:Saprisartan, GR-138950C(K salt), GR-138950X, GR-138950
Synthetic route:
Synthetic Methods:1) The reaction of 5-methylbenzofuran (I) with triisopropyl borate by means of butyllithium and tetramethylethylenediamine (TMEDA) in ethyl ether gives 5-methylbenzofuran-2-boronic acid (II), which is condensed with methyl 2-bromobenzoate (III) by means of tetrakis(triphenylphosphine)palladium yielding 2-(5-methylbenzofuran-2-yl)benzoic acid methyl ester (IV). The ...
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tert-butyl N-[2-[3-bromo-5-(bromomethyl)-1-benzofuran-2-yl]phenyl]carbamate
March 24th, 2008
Chemical:tert-butyl N-[2-[3-bromo-5-(bromomethyl)-1-benzofuran-2-yl]phenyl]carbamate
CAS:
Structure:
Formula:C20H19Br2NO3
Formula mass:481.1873
Synthesis:
Target product:Saprisartan, GR-138950C(K salt), GR-138950X, GR-138950
Synthetic route:
Synthetic Methods:1) The reaction of 5-methylbenzofuran (I) with triisopropyl borate by means of butyllithium and tetramethylethylenediamine (TMEDA) in ethyl ether gives 5-methylbenzofuran-2-boronic acid (II), which is condensed with methyl 2-bromobenzoate (III) by means of tetrakis(triphenylphosphine)palladium yielding 2-(5-methylbenzofuran-2-yl)benzoic acid methyl ester (IV). The ...
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ethyl 4-cyclopropyl-2-ethyl-1H-imidazole-5-carboxylate
March 24th, 2008
Chemical:ethyl 4-cyclopropyl-2-ethyl-1H-imidazole-5-carboxylate
CAS:
Structure:
Formula:C11H16N2O2
Formula mass:208.2624
Synthesis:
Target product:Saprisartan, GR-138950C(K salt), GR-138950X, GR-138950
Synthetic route:
Synthetic Methods:1) The reaction of 5-methylbenzofuran (I) with triisopropyl borate by means of butyllithium and tetramethylethylenediamine (TMEDA) in ethyl ether gives 5-methylbenzofuran-2-boronic acid (II), which is condensed with methyl 2-bromobenzoate (III) by means of tetrakis(triphenylphosphine)palladium yielding 2-(5-methylbenzofuran-2-yl)benzoic acid methyl ester (IV). The ...
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tert-butyl N-[2-(3-bromo-5-methyl-1-benzofuran-2-yl)phenyl]carbamate
March 24th, 2008
Chemical:tert-butyl N-[2-(3-bromo-5-methyl-1-benzofuran-2-yl)phenyl]carbamate
CAS:
Structure:
Formula:C20H20BrNO3
Formula mass:402.2913
Synthesis:
Target product:Saprisartan, GR-138950C(K salt), GR-138950X, GR-138950
Synthetic route:
Synthetic Methods:1) The reaction of 5-methylbenzofuran (I) with triisopropyl borate by means of butyllithium and tetramethylethylenediamine (TMEDA) in ethyl ether gives 5-methylbenzofuran-2-boronic acid (II), which is condensed with methyl 2-bromobenzoate (III) by means of tetrakis(triphenylphosphine)palladium yielding 2-(5-methylbenzofuran-2-yl)benzoic acid methyl ester (IV). The ...
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methyl 2-(5-methyl-1-benzofuran-2-yl)benzoate
March 24th, 2008
Chemical:methyl 2-(5-methyl-1-benzofuran-2-yl)benzoate
CAS:
Structure:
Formula:C17H14O3
Formula mass:266.2993
Synthesis:
Target product:Saprisartan, GR-138950C(K salt), GR-138950X, GR-138950
Synthetic route:
Synthetic Methods:1) The reaction of 5-methylbenzofuran (I) with triisopropyl borate by means of butyllithium and tetramethylethylenediamine (TMEDA) in ethyl ether gives 5-methylbenzofuran-2-boronic acid (II), which is condensed with methyl 2-bromobenzoate (III) by means of tetrakis(triphenylphosphine)palladium yielding 2-(5-methylbenzofuran-2-yl)benzoic acid methyl ester (IV). The ...
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2-(3-bromo-5-methyl-1-benzofuran-2-yl)benzoic acid
March 24th, 2008
Chemical:2-(3-bromo-5-methyl-1-benzofuran-2-yl)benzoic acid
CAS:
Structure:
Formula:C16H11BrO3
Formula mass:331.1683
Synthesis:
Target product:Saprisartan, GR-138950C(K salt), GR-138950X, GR-138950
Synthetic route:
Synthetic Methods:1) The reaction of 5-methylbenzofuran (I) with triisopropyl borate by means of butyllithium and tetramethylethylenediamine (TMEDA) in ethyl ether gives 5-methylbenzofuran-2-boronic acid (II), which is condensed with methyl 2-bromobenzoate (III) by means of tetrakis(triphenylphosphine)palladium yielding 2-(5-methylbenzofuran-2-yl)benzoic acid methyl ester (IV). The ...
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methyl 2-(3-bromo-5-methyl-1-benzofuran-2-yl)benzoate
March 24th, 2008
Chemical:methyl 2-(3-bromo-5-methyl-1-benzofuran-2-yl)benzoate
CAS:
Structure:
Formula:C17H13BrO3
Formula mass:345.1954
Synthesis:
Target product:Saprisartan, GR-138950C(K salt), GR-138950X, GR-138950
Synthetic route:
Synthetic Methods:1) The reaction of 5-methylbenzofuran (I) with triisopropyl borate by means of butyllithium and tetramethylethylenediamine (TMEDA) in ethyl ether gives 5-methylbenzofuran-2-boronic acid (II), which is condensed with methyl 2-bromobenzoate (III) by means of tetrakis(triphenylphosphine)palladium yielding 2-(5-methylbenzofuran-2-yl)benzoic acid methyl ester (IV). The ...
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(3S,4R)-3-((1R)-1-[[tert-butyl(dimethyl)silyl]oxy]ethyl)-4-[(1S,2R,6R)-7-oxabicyclo[4.1.0]hept-2-yl]-2-azetidinone
March 24th, 2008
Chemical:(3S,4R)-3-((1R)-1-[[tert-butyl(dimethyl)silyl]oxy]ethyl)-4-[(1S,2R,6R)-7-oxabicyclo[4.1.0]hept-2-yl]-2-azetidinone
CAS:
Structure:
Formula:C17H31NO3Si
Formula mass:325.5275
Synthesis:
Target product:Sanfetrinem cilexetil, GV-118819
Synthetic route:
Synthetic Methods:2) The condensation of the previously referenced azetidinone (III) with 1-(trimethylsilyloxy)cyclohexene (XVI) by means of trimethylsilyloxy trifluoromethanesulfonate in acetonitrile gives the corresponding addition product (XVII), which by reaction first with p-toluenesulfonyl hydrazide in acetic acid and then with lithium diisopropylamide in THF yields the ...
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[5-hydroxy-4-[([2-[([3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinyl]methyl)amino]ethyl]amino)methyl]-6-methyl-3-pyridinyl]methyl dihydrogen phosphate
March 24th, 2008
Chemical:[5-hydroxy-4-[([2-[([3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinyl]methyl)amino]ethyl]amino)methyl]-6-methyl-3-pyridinyl]methyl dihydrogen phosphate
CAS:
Structure:
Formula:C18H28N4O10P2
Formula mass:522.3923
Synthesis:
Target product:Manganese dipyridoxal diphosphate trisodium salt, Mangafodipir trisodium, Win-59010-2, S-095, MnDPDP, Teslascan
Synthetic route:
Synthetic Methods:The condensation of pyridoxal 5-phosphate (I) with ethylenediamine (II) in methanol by means of NaOH gives the corresponding diimine (III), which is reduced with hydrogen over Pt/C in methanol/water yielding the expected diamine (IV). ...
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